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Potato starch supplements considered for bone marrow transplants

source : www.nutritioninsight.com




October 24, 2023 — Researchers at the University of Michigan Health Rogel Cancer Center are testing the potential of potato starch supplements to prevent a dangerous complication in stem cell transplant patients using blood or bone marrow from a donor.

Patients receive a new immune system when they undergo a stem cell transplant. The donor’s immune system attacks cells that do not belong in the body, such as cancer cells. The transplant of donor cells then begins to view the patient’s body as foreign and attacks the organs and tissues, causing Graft Versus Host Disease (GVHD).

GVHD is a major limitation to the lifesaving potential of blood or bone marrow stem cell transplants, says Dr. Mary Riwes, medical director of the adult inpatient stem cell transplant unit of the Medical Directors Partnering to Lead along with Nurse Managers program.

“It is exciting to think about the prospect of finding a simple, cheap and safe approach to reduce this dangerous complication for patients requiring a stem cell transplant, but research into this approach in more patients is still needed to determine this.” to confirm.”

Changed bacterial direction
In a test with ten patients, researchers found that a dietary supplement made from potato starch changed the byproducts of gut bacteria in a way that could potentially prevent GVHD.

Researchers are enrolling patients in a second clinical trial phase to determine whether taking potato starch will reduce GVHD after a stem cell transplant. Sixty patients undergoing a blood or bone marrow stem cell transplant who are ten years of age or older will be randomized to take potato starch or placebo starch and all common medications to prevent GVHD.Doctor and patientPotato starch is considered an alternative method to recover from stem cell transplants and prevent GVHD.

Phase II will help researchers find out whether or not taking potato starch is an effective intervention to prevent GVHD, with 80% of patients in the experiment taking potato starch and 20% taking placebo starch.

Cut back on powerful medications
GVHD is usually treated with strong medications that suppress the immune system. This causes patients to develop life-threatening infections.

Although bone marrow and blood stem cell transplants from a donor are lifesaving for many patients with various serious diseases, the development of GVHD can cause injury or even death and the available treatments for GVHD are risky.

Previous research has shown that the bacteria that normally live in the intestines and their products can influence whether GVHD is contracted after a transplant.

GVHD develops in about half of patients who undergo stem cell transplants and can affect many parts of the body. Approximately 9,000 transplants are performed in the US each year.

Meanwhile, Prolacta Bioscience has made a synbiotic breakthrough by using sugars from breast milk oligosaccharides, a strain of bacteria found in infants, to precisely heal the gut microbiome of adults.

By Inga de Jong

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source : www.nutritioninsight.com

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